The question worth asking
Compare the evidence for ketamine, esketamine, and psilocybin in depression, including approvals and limitations.
This page is a navigation guide, not a condition-specific clinical guideline. A medicine being researched for a condition does not establish approval, effectiveness, durability, or suitability for an individual.
Read a study in context
- Who was included—and who was excluded? Check the diagnosis, age, medical history, and setting.
- Was the study randomized and controlled, observational, a case report, or a preprint?
- What changed, for how long, and compared with what? Separate symptom scores from everyday functioning.
- Were harms, dropouts, blinding problems, and conflicts of interest reported?
- What established care and non-drug support should remain part of the conversation?
Explore related language
Major depressive disorder · Treatment-resistant depression