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Papers, trials, safety signals, systematic reviews, case reports, preprints, and policy records—organized by source, date, evidence type, and editorial state.

Educational boundary. The bot detects source metadata; it does not decide what is medically true. “Submitted” means not yet interpreted or approved by Pō a Ao. A trial registration, preprint, abstract, or case report is not a treatment recommendation.

01 · 194 detected

Clinical trials

New and updated registry records. Registration does not establish safety, effectiveness, completion, or published results.

02 · 12 detected

Safety & interactions

Adverse-event, toxicity, contraindication, interaction, monitoring, and harm-reduction records.

03 · 26 detected

Systematic reviews

Systematic, scoping, umbrella, and meta-analytic records with methods and limitations still requiring appraisal.

04 · 9 detected

Case reports

Individual reports and small series that may identify signals but cannot estimate typical outcomes.

05 · 32 detected

Preprints

Public manuscripts that may not have completed peer review and may change or be withdrawn.

06 · 5 detected

Policy & law

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Longitudinal peripheral DNA methylation remodeling following ketamine-assisted psychotherapy in major depressive disorder.

Epigenetics · Date not supplied · ketamine

Sources checked every day.New records when found.

Clinical trials

Safety & interactions

Systematic reviews

Case reports

Preprints

Policy & law

Most recently detected

Longitudinal peripheral DNA methylation remodeling following ketamine-assisted psychotherapy in major depressive disorder.

Ketamine in Modern Medicine: Current Evidence in Acute Pain, Opioid Use Disorder, and Depression.

Adapted Massed Exposure Therapy Enhanced with MDMA for PTSD (aMETEMP): A randomized, double-masked protocol adapted for Veterans Affairs healthcare system.

Magnetic solid-phase extraction coupled with fluorescent lateral flow immunoassay for simultaneous on-site detection of methamphetamine, morphine, and ketamine in wastewater.

Extracellular flux analysis and proteomic profiling indicate ibogaine promotes synaptic plasticity and neural repair by a metabolic preconditioning mechanism.

Ketamine's mechanisms of action in major depressive disorder and treatment-resistant depression: Is brain topological change a candidate convergent systems-level pathway?

Safety and efficacy of psilocybin-assisted therapy for alcohol use disorder: Open-label extension of a phase II randomized controlled trial.

Dexmedetomidine versus Subanaesthetic Ketamine for Opioid-sparing Anaesthesia During Lumbar Spine Surgery Under a Standardised Surgical Pleth Index-guided Analgesic Protocol: A Randomised Controlled Trial.

Analysis of Ketamine, Its Metabolites, and Analogs in Urine by DLLME and LC-MS/MS.

µ-QuEChERS as a Clean-Up Strategy for Determination of Ketamine, Cocaine, and Metabolites in Hair Samples.

Subanesthetic ketamine modulates region-specific neural and endocrine responses to acute stress in rats.

Suicidality during intranasal (es)ketamine treatment: A retrospective cohort study.

Low-dose ketamine modulates brain entropy in treatment-resistant depression: Results from two neuroimaging clinical trials.

Effects of psilocybin with psychological support on anhedonia in treatment-resistant depression: A randomized controlled pilot trial.

Ketamine Vs. Etomidates and Cardiovascular Collapse During Emergency Tracheal Intubation: A Secondary Analysis of the DEVICE and PREOXI Trials.

Patient Safety and Regulatory Transparency on Ketamine Clinic Websites in South Florida: A Cross-Sectional Audit.

Changes in self-related cognitive processes and depressive symptom severity following a single, moderate dose of psilocybin in depressed patients.

Psychedelic ego-dissolution: a philosophical and qualitative critique.

The "dark magic mushroom" co-produces amatoxins and psilocybin.

From Rapid Synaptic Events to Lasting Antidepressant States: Convergent and Divergent Mechanisms of Ketamine and Psychedelics.

Behavioural profiling of social and locomotor responses to repeated ketamine exposure in adult zebrafish.

Changes in wellbeing, self-compassion and alexithymia in a proof of principle trial with MDMA-assisted therapy for major depressive disorder.

Ketamine for co-occurring chronic pain and depression: A scoping review highlighting the dual-outcome evidence gap and its treatment and research implications.

Psilocybin enhances conditioned place preference learning in planarians.

Lidocaine-ketamine-propofol total intravenous anesthesia in two chinchillas (Chinchilla lanigera).

Efficacy and safety of ketamine for post-traumatic stress disorder: A systematic review with narrative synthesis and consideration of military and veteran populations.

Effects of ketamine and dexmedetomidine on ischemia- reperfusion injury in an experimental renal ischemia model.

Randomized controlled trial of acute ketamine versus midazolam for recurrence of suicidality in adolescents (TASK): Rationale, design, and baseline characteristics.

Efficacy and safety of psilocybin-assisted therapy for alcohol use disorder: A systematic review and meta-analysis.

Clinical Factors Associated With Early Ketamine Initiation Among Mechanically Ventilated Adults: A Retrospective MIMIC-IV Cohort Study.

Sources checked every day.
New records when found.