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Research ledger · Source metadata

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500 records available.

The available automated discovery ledger across indexed sources and registries.

Educational boundary. Automatically detected metadata is not a medical conclusion, endorsement, or quality rating. Open the source, examine methods and population, and wait for appropriate review before applying a finding.

Ledger source: Database ledger. Last collected/checked: Nov 13, 2026, 5:16 AM UTC. This ledger timestamp is within the last 48 hours.

research-article
submitted

Longitudinal peripheral DNA methylation remodeling following ketamine-assisted psychotherapy in major depressive disorder.

Epigenetics · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine in Modern Medicine: Current Evidence in Acute Pain, Opioid Use Disorder, and Depression.

Advances in anesthesia · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Adapted Massed Exposure Therapy Enhanced with MDMA for PTSD (aMETEMP): A randomized, double-masked protocol adapted for Veterans Affairs healthcare system.

Contemporary clinical trials communications · Date not supplied

mdmaclinical-evidenceveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Magnetic solid-phase extraction coupled with fluorescent lateral flow immunoassay for simultaneous on-site detection of methamphetamine, morphine, and ketamine in wastewater.

Analytica chimica acta · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Extracellular flux analysis and proteomic profiling indicate ibogaine promotes synaptic plasticity and neural repair by a metabolic preconditioning mechanism.

European journal of pharmacology · Date not supplied

ibogaineibogamechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine's mechanisms of action in major depressive disorder and treatment-resistant depression: Is brain topological change a candidate convergent systems-level pathway?

Asian journal of psychiatry · Date not supplied

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Safety and efficacy of psilocybin-assisted therapy for alcohol use disorder: Open-label extension of a phase II randomized controlled trial.

Drug and alcohol dependence · Date not supplied

psilocybinsafetyclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Dexmedetomidine versus Subanaesthetic Ketamine for Opioid-sparing Anaesthesia During Lumbar Spine Surgery Under a Standardised Surgical Pleth Index-guided Analgesic Protocol: A Randomised Controlled Trial.

Turkish journal of anaesthesiology and reanimation · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Analysis of Ketamine, Its Metabolites, and Analogs in Urine by DLLME and LC-MS/MS.

Methods in molecular biology (Clifton, N.J.) · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

µ-QuEChERS as a Clean-Up Strategy for Determination of Ketamine, Cocaine, and Metabolites in Hair Samples.

Methods in molecular biology (Clifton, N.J.) · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Subanesthetic ketamine modulates region-specific neural and endocrine responses to acute stress in rats.

Neuropharmacology · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Suicidality during intranasal (es)ketamine treatment: A retrospective cohort study.

Journal of affective disorders · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Low-dose ketamine modulates brain entropy in treatment-resistant depression: Results from two neuroimaging clinical trials.

Journal of affective disorders · Date not supplied

ketamineclinical-evidencemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Effects of psilocybin with psychological support on anhedonia in treatment-resistant depression: A randomized controlled pilot trial.

Journal of affective disorders · Date not supplied

psilocybinclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine Vs. Etomidates and Cardiovascular Collapse During Emergency Tracheal Intubation: A Secondary Analysis of the DEVICE and PREOXI Trials.

Critical care explorations · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
policy-law
submitted

Patient Safety and Regulatory Transparency on Ketamine Clinic Websites in South Florida: A Cross-Sectional Audit.

Journal of psychiatric practice · Date not supplied

ketaminesafetypolicy-law
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Changes in self-related cognitive processes and depressive symptom severity following a single, moderate dose of psilocybin in depressed patients.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences · Date not supplied

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psychedelic ego-dissolution: a philosophical and qualitative critique.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences · Date not supplied

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

The "dark magic mushroom" co-produces amatoxins and psilocybin.

Current biology : CB · Date not supplied

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

From Rapid Synaptic Events to Lasting Antidepressant States: Convergent and Divergent Mechanisms of Ketamine and Psychedelics.

The Journal of neuroscience : the official journal of the Society for Neuroscience · Date not supplied

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Behavioural profiling of social and locomotor responses to repeated ketamine exposure in adult zebrafish.

Royal Society open science · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Changes in wellbeing, self-compassion and alexithymia in a proof of principle trial with MDMA-assisted therapy for major depressive disorder.

Journal of psychiatric research · Date not supplied

mdmaclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

Ketamine for co-occurring chronic pain and depression: A scoping review highlighting the dual-outcome evidence gap and its treatment and research implications.

The journal of pain · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psilocybin enhances conditioned place preference learning in planarians.

Behavioural pharmacology · Date not supplied

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Lidocaine-ketamine-propofol total intravenous anesthesia in two chinchillas (Chinchilla lanigera).

Veterinary anaesthesia and analgesia · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

Efficacy and safety of ketamine for post-traumatic stress disorder: A systematic review with narrative synthesis and consideration of military and veteran populations.

PCN reports : psychiatry and clinical neurosciences · Date not supplied

ketaminesafetyclinical-evidenceveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Effects of ketamine and dexmedetomidine on ischemia- reperfusion injury in an experimental renal ischemia model.

Experimental and therapeutic medicine · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Randomized controlled trial of acute ketamine versus midazolam for recurrence of suicidality in adolescents (TASK): Rationale, design, and baseline characteristics.

Contemporary clinical trials · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
meta-analysis
submitted

Efficacy and safety of psilocybin-assisted therapy for alcohol use disorder: A systematic review and meta-analysis.

Journal of psychopharmacology (Oxford, England) · Date not supplied

psilocybinsafetyclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Clinical Factors Associated With Early Ketamine Initiation Among Mechanically Ventilated Adults: A Retrospective MIMIC-IV Cohort Study.

Anesthesiology research and practice · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Stellate Ganglion Block Combined With Subanesthetic Ketamine Versus Dexmedetomidine for the Management of Paroxysmal Sympathetic Hyperactivity (PSH) After Traumatic Brain Injury: A Randomized Trial.

Critical care research and practice · Date not supplied

ketamineclinical-evidencemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

The ketamine bladder.

Australian journal of general practice · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Chronic Mild Stress in Male Wistar-Kyoto Rats Induces Long-Term Hippocampal Plasticity Impairments Differentially Reversed by Acute and Chronic Ketamine Treatment.

The European journal of neuroscience · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

From Evidence to Practice: A Systematic Review of Implementation of Psychedelic-Assisted Psychotherapy.

Psychedelic medicine (New Rochelle, N.Y.) · Date not supplied

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine/Esketamine in Clinical Practice: Areas of Consensus and Nonconsensus from an American Society of Clinical Psychopharmacology (ASCP) Delphi Panel Task Force.

The Journal of clinical psychiatry · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

Psilocybin-Assisted Therapy for Cancer-Related Psychological and Existential Distress in Adults with Cancer: An Integrative Systematic Review.

Journal of pain & palliative care pharmacotherapy · Date not supplied

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Working memory neural correlates after ketamine in treatment-resistant depression: a randomized placebo-controlled functional magnetic resonance imaging study.

Psychiatry research. Neuroimaging · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Next-Generation Psychedelic Drug Development.

ACS chemical neuroscience · Date not supplied

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

From Toad Venom to Drug Development: The Clinical Pharmacology of Mebufotenin (5-MeO-DMT) in Treatment-Resistant Depression.

CNS drugs · Date not supplied

5-meo-dmtdmt
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Intermittent theta burst stimulation to extend early ketamine response in treatment-resistant depression: A preliminary enriched randomized, double-blind, sham-controlled trial.

Psychiatry and clinical neurosciences · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
policy-law
submitted

Psilocybin modulates nucleus accumbens activity via astrocytic transcriptional regulation.

Experimental & molecular medicine · Date not supplied

psilocybinpolicy-law
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine, an interoceptive associative agent? Evidence from ketamine-assisted Mindfulness-Oriented Recovery Enhancement for opioid use disorder.

Journal of psychopharmacology (Oxford, England) · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
safety-study
submitted

Critical adverse events during emergency department ketamine-propofol sedation in children.: A secondary analysis of a multicentre study.

European journal of anaesthesiology · Date not supplied

ketaminesafety
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Pharmacist Guide to Psilocybin and Psychedelic-Assisted Psychotherapy.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · Date not supplied

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

MDMA-assisted therapy for social anxiety disorder: A randomized, open-label, wait-list controlled trial.

Journal of affective disorders · Date not supplied

mdmaclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine-induced cholangiopathy in a child with febrile infection-related epilepsy syndrome.

Epileptic disorders : international epilepsy journal with videotape · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

Exploring the durability of esketamine and ketamine's antidepressant effects in the maintenance phase of treatment: A systematic review.

Psychiatry research · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ayahuasca treatment reduces 50-kHz ultrasonic vocalizations and modifies mesocorticolimbic monoamine neurochemistry in rats.

Pharmacology, biochemistry, and behavior · Date not supplied

ayahuascamechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Alternative visions: The strategic partial medicalization of ibogaine treatment.

Social science & medicine (1982) · Date not supplied

ibogaineiboga
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Depression: Ketamine quiets an unruly habenula.

Current biology : CB · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Bridging Suicidal Crisis to Outpatient Care: Could Ketamine Plus Buprenorphine Shift the Paradigm?

The Journal of clinical psychiatry · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Direct Quantitation of Psilocybin and Psilocin by (1)H and (31)P qNMR in Wild Psilocybe from Greece.

ACS omega · Date not supplied

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Impact of Histopathology and Bladder Dysfunction on the Treatment Strategy Selection of Ketamine-Associated Cystitis.

Lower urinary tract symptoms · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

How Psilocybin Alters Consciousness: Psychedelics can create a "hidden order" in brain activity that could explain how these drugs affect our sense of self.

Scientific American · Date not supplied

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Rapid antidepressant effects of ketamine combined with selective serotonin reuptake inhibitors: Mechanisms and outlook.

Journal of psychiatric research · Date not supplied

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
safety-study
submitted

The Fireside Database: Large-scale evidence from 25,419 psychedelic support interactions.

Science advances · Date not supplied

interactions
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

MDMA-Assisted Therapy for Veterans with Comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: Clinical Outcomes from the First Open-Label Pilot Trial.

Alcohol (Fayetteville, N.Y.) · Date not supplied

mdmaclinical-evidenceveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine metabolite HNK ameliorates anhedonia symptom in Alzheimer's disease mice.

Biochemical and biophysical research communications · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

5-HT(2A) receptors in layer 5 pyramidal neurons mediate the neuroplastic but not the hallucinogenic effects of psilocybin.

Nature neuroscience · Date not supplied

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Sex differences in recovery from ketamine anesthesia.

Lab animal · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
case-report
submitted

Paediatric Ketamine Bladder Case Report: A Burgeoning Problem in the Paediatric Population.

Case reports in pediatrics · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Consent beyond the written form: Implications for ketamine trials in the Philippines.

Therapeutic advances in psychopharmacology · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Expression of Concern for Magnesium and Ketamine Gargle and Postoperative Sore Throat [Anesth Pain Med. 2015; 5 (3): e22367].

Anesthesiology and pain medicine · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

The role of ventral tegmental area dopamine neurons in emergence from dexmedetomidine, fentanyl, and ketamine anesthesia in rats.

Anesthesiology · Date not supplied

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Intravenous Ketamine reduces psychological pain in suicidal inpatients: A secondary analysis of a six-week randomized placebo-controlled trial.

Journal of affective disorders · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

Subacute and long-term changes in cognitive functioning after administration of classic psychedelics, MDMA and ketamine: A systematic review of clinical and preclinical evidence.

Neuroscience and biobehavioral reviews · Date not supplied

ketaminemdma
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
safety-study
submitted

Comment on "KET-MCI: A Pilot Safety and Tolerability Study of Single Infusion Intravenous Ketamine for Older Adults With Depression and Mild Cognitive Impairment".

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · Date not supplied

ketaminesafety
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
safety-study
submitted

Single-Infusion Ketamine in Older Adults With Depression and Mild Cognitive Impairment: Promising Signal, Falls, and Cognitive Safety Need Closer Scrutiny.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · Date not supplied

ketaminesafety
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Depression Heterogeneity as a Confounder in Ketamine Response for Late-Life Depression.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
safety-study
submitted

Ketamine Safety and Therapeutic Opportunity in Late-Life Depression With Depression-Executive Dysfunction Syndrome (DED).

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · Date not supplied

ketaminesafety
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Baricitinib ameliorates behavioral deficits and NLRP3-related neuroinflammation in a ketamine rat model of schizophrenia: Role of JAK2/STAT3 and PI3K/AKT/mTOR signaling.

International immunopharmacology · Date not supplied

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
meta-analysis
submitted

Efficacy and Safety of Psychedelic Microdosing on Psychological Outcomes in Healthy Adults: A Systematic Review and Meta-analysis.

CNS drugs · Date not supplied

safetyclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
safety-study
submitted

Ketamine administration and postoperative mortality after major cancer surgery: a propensity-matched population-based study.

British journal of anaesthesia · Date not supplied

ketaminesafety
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ibogaine as a double-edged sword: Developmental cardiotoxicity and neurobehavioral alterations in zebrafish.

Behavioural brain research · Date not supplied

ibogaineibogasafetymechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Effects of ketamine infusion rate and cumulative dosing on incidence of delirium in medical intensive care unit patients.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Operationalizing Excellence in Psychedelic Care Through Advancing Competencies in Nurses: State-of-the Science Review.

Issues in mental health nursing · Date not supplied

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
case-report
submitted

Ketamine Use Disorder and Entrenchment of Delusional Beliefs: A Case Report.

Journal of addiction medicine · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psilocybin use, mental health treatment utilization, and unmet treatment need among US individuals with depression.

Psychological medicine · Date not supplied

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Molecular snapshots confirm ketamine's opioid nature.

Nature structural & molecular biology · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

An integrative model of ketamine-induced memory dysfunction: From synapse to circuit in clinical context.

Neurotoxicology · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Optimizing Ketamine Infusion Therapy for Treatment-Resistant Bipolar Depression: Commentary on Zhou et al. (2023).

Bipolar disorders · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

A Progressive Shift in Procedural Sedation: Is It Time to Embrace Ketamine in Interventional Radiology?

Radiology · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine Plus Midazolam versus Fentanyl Plus Midazolam for Sedation and Analgesia during Image-guided Procedures in Interventional Radiology: Randomized Clinical Trial.

Radiology · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine: from anesthesia to pediatric suicidal crisis.

CJEM · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine enhances ketogenic diet-induced resilience to activity-based anorexia of adult mice through hippocampal synaptic plasticity.

Neuroscience · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine assisted psychotherapy to reduce chronic neuropathic pain: A mixed-methods randomized pilot trial.

Med (New York, N.Y.) · Date not supplied

ketamineclinical-evidencemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine Analgesia for Refractory Mucositis Pain (KARM): A prospective, double-blind, randomised, phase 2 study of ketamine for oral and pharyngeal mucositis pain.

Journal of pain and symptom management · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Prolonged Micromolar Ketamine Exposure Induces Dorsal Spinal Neuron Apoptosis and Locomotor Deficits During Early Development: Insights From FRET-Based Sensor Zebrafish.

Journal of applied toxicology : JAT · Date not supplied

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Opioid-Sparing Sedation for Gastrostomy Tube Placement: A Retrospective Cohort Study Comparing Ketamine/Midazolam and Fentanyl/Midazolam.

Journal of vascular and interventional radiology : JVIR · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Resetting the hippocampal buffer: a neurocognitive account of psychedelic therapy for anxiety-related psychopathology.

Psychopharmacology · Date not supplied

mechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine attenuates habenula activity in response to aversive outcomes during Pavlovian learning.

Current biology : CB · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Serial Ketamine Infusions for Treatment-Resistant Bipolar Depression: A Randomized Clinical Trial.

JAMA psychiatry · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Heterogeneous structural brain signatures of methamphetamine and ketamine use disorders revealed by normative modeling.

Molecular psychiatry · Date not supplied

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Impact of different anesthetic agents (propofol, etomidate, ketamine) on seizure duration and cognitive recovery in electroconvulsive therapy.

World journal of methodology · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

A Multi-Site Evaluation of a Psychedelic Medicine Curriculum for Psychiatry Trainees.

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry · Date not supplied

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Subacute effects of ketamine on neural correlates of reward processing.

Translational psychiatry · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine in ambulatory anesthesia: dose-dependent effects on breathing and cortical function.

Current opinion in anaesthesiology · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

A rapid systematic review of palliative uses of ketamine for depression and pain in people living with advanced cancer.

Annals of palliative medicine · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Oral ketamine adjunct for wound care in patients with burn injuries.

Journal of burn care & research : official publication of the American Burn Association · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Neuroprotective effects of ketamine, lamotrigine, and ketoprofen combinations after pars plana vitrectomy and silicone oil injection.

International ophthalmology · Date not supplied

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Metabolomic correlates of intravenous racemic ketamine in treatment-resistant major depressive disorder: the Bio-K/NNDC multicenter trial.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

The effect of ketamine on mitochondrial bioenergetics, viability, and function: A systematic review.

Journal of psychopharmacology (Oxford, England) · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine for Analgosedation in Mechanically Ventilated Adults: A Double-Blind Randomized Trial.

Critical care medicine · Date not supplied

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Comparison of subanaesthetic ketamine and lidocaine as adjuvants to propofol-based total intravenous anesthesia on propofol requirement during emergency decompressive craniectomy for traumatic brain injury: a prospective, double-blind, three-arm randomized controlled trial.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · Date not supplied

ketamineclinical-evidencemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine versus alternate agents to prevent postinduction haemodynamic instability during tracheal intubation of critically ill adults. Response to Br J Anaesth Advance Access published on Jul 20, 2026, doi: 10.1016/j.bja.2026.05.034.

British journal of anaesthesia · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psychedelic 4-AcO-DMT attenuated looming-induced freezing behaviors by activating PrL (CaMKIIα) neurons in mice.

Molecular psychiatry · Date not supplied

dmtmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine-Induced Dissociation as an Ethical Signal, Not a Side Effect: Context as the Determinant of Clinical Duties Under Beneficence and Non-maleficence.

HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues · Date not supplied

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psilocybin enhances conditioned place preference learning in planarians.

Europe PMC · 11/13/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Connectedness as a candidate pathway linking psilocybin retreat experiences to sustained wellbeing: a prospective naturalistic study

Europe PMC · 11/12/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

How Does Psilocybin Affect Daily Life Experience and Behavior? Protocol For a Multimethod Ambulatory Assessment Study Within a Clinical Trial of Psilocybin for Depression

Europe PMC · 11/12/2026

psilocybinclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Behavioural profiling of social and locomotor responses to repeated ketamine exposure in adult zebrafish.

Europe PMC · 11/11/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine for Treatment-Resistant Depression.

Europe PMC · 11/11/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

DMT and harmine responses in monocyte-derived microglia- like cells from patients with treatment-resistant depression

Europe PMC · 11/11/2026

dmt
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

The "dark magic mushroom" co-produces amatoxins and psilocybin.

Europe PMC · 11/11/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

From Rapid Synaptic Events to Lasting Antidepressant States: Convergent and Divergent Mechanisms of Ketamine and Psychedelics.

Europe PMC · 11/11/2026

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Exploring subacute effects of a DMT and harmine meditation retreat on the brain's control energy landscape

Europe PMC · 11/11/2026

dmtmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine Vs. Etomidates and Cardiovascular Collapse During Emergency Tracheal Intubation: A Secondary Analysis of the DEVICE and PREOXI Trials.

Europe PMC · 11/10/2026

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Low-Dose Propofol, Ketamine, and Their Combination for the Prevention of Post-Extubation Cough and Laryngospasm in Patients Undergoing Gynecologic Laparotomy: A Randomized Controlled Trial

Europe PMC · 11/10/2026

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

A Placebo Cannot Be Psychedelic: Why psychedelic trials need dose, not mimicry, as their control

Europe PMC · 11/10/2026

clinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Beyond dose. Perceived group support as a person-level predictor of emotional breakthrough and psychological insight during DMT–harmine administration

Europe PMC · 11/10/2026

dmt
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

Ketamine for co-occurring chronic pain and depression: A scoping review highlighting the dual-outcome evidence gap and its treatment and research implications.

Europe PMC · 11/9/2026

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Rapid antidepressant effects of psilocybin without increased SV2A binding: baseline binding predicts response

Europe PMC · 11/8/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine-induced cholangiopathy in a child with febrile infection-related epilepsy syndrome.

Europe PMC · 11/7/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Changes in wellbeing, self-compassion and alexithymia in a proof of principle trial with MDMA-assisted therapy for major depressive disorder.

Europe PMC · 11/7/2026

mdmaclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
safety-study
submitted

Critical adverse events during emergency department ketamine-propofol sedation in children.: A secondary analysis of a multicentre study.

Europe PMC · 11/6/2026

ketaminesafety
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Pharmacist Guide to Psilocybin and Psychedelic-Assisted Psychotherapy.

Europe PMC · 11/6/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

MDMA-assisted therapy for social anxiety disorder: A randomized, open-label, wait-list controlled trial.

Europe PMC · 11/6/2026

mdmaclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Cell-type specific modulation of dorsal raphe serotonergic neurons by ketamine.

Europe PMC · 11/5/2026

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine, an interoceptive associative agent? Evidence from ketamine-assisted Mindfulness-Oriented Recovery Enhancement for opioid use disorder.

Europe PMC · 11/5/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

A Topology of the Psilocybin Experience Reveals Cognitive-Emotional Drivers, Unitive State Divergence, and Psychometric Feature Cancellation

Europe PMC · 11/5/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
policy-law
submitted

Psilocybin modulates nucleus accumbens activity via astrocytic transcriptional regulation.

Europe PMC · 11/5/2026

psilocybinpolicy-law
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Context-dependent effects of ketamine on emotional evidence integration

Europe PMC · 11/4/2026

ketamineintegration
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Intermittent theta burst stimulation to extend early ketamine response in treatment-resistant depression: A preliminary enriched randomized, double-blind, sham-controlled trial.

Europe PMC · 11/4/2026

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Stellate Ganglion Block Combined With Subanesthetic Ketamine Versus Dexmedetomidine for the Management of Paroxysmal Sympathetic Hyperactivity (PSH) After Traumatic Brain Injury: A Randomized Trial.

Europe PMC · 11/4/2026

ketamineclinical-evidencemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Clinical Factors Associated With Early Ketamine Initiation Among Mechanically Ventilated Adults: A Retrospective MIMIC-IV Cohort Study.

Europe PMC · 11/4/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Scn2a -deficient mice exhibit serotonergic dysfunction and altered behavioral responses to psilocybin

Europe PMC · 11/4/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

From Toad Venom to Drug Development: The Clinical Pharmacology of Mebufotenin (5-MeO-DMT) in Treatment-Resistant Depression.

Europe PMC · 11/4/2026

5-meo-dmtdmt
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Preoperative emotional stress and postoperative pain after lumbar fusion surgery: secondary analysis of a randomized trial of adjunctive S-ketamine in oxycodone patient-controlled analgesia

Europe PMC · 11/3/2026

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Working memory neural correlates after ketamine in treatment-resistant depression: a randomized placebo-controlled functional magnetic resonance imaging study.

Europe PMC · 11/3/2026

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Dyskinesia induced by a dopamine 2 receptor-like agonist, but not a dopamine 1 receptor-like agonist, is blocked by sub-anesthetic ketamine

Europe PMC · 11/3/2026

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

The anti-dyskinetic and the anti-parkinsonian effects of sub-anesthetic ketamine are also present in female preclinical models

Europe PMC · 11/3/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

Psilocybin-Assisted Therapy for Cancer-Related Psychological and Existential Distress in Adults with Cancer: An Integrative Systematic Review.

Europe PMC · 11/3/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine/Esketamine in Clinical Practice: Areas of Consensus and Nonconsensus from an American Society of Clinical Psychopharmacology (ASCP) Delphi Panel Task Force.

Europe PMC · 11/2/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Enantioselective Analysis of Ketamine and Other Substances Commonly Found in "Pink Cocaine" Preparations via Capillary Electrophoresis and Liquid Chromatography With Ultraviolet Detection.

Europe PMC · 11/2/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
case-report
submitted

Oral administration of parenteral S-ketamine in wound care when 'conventional' medication regimens are not sufficient: a case series.

Europe PMC · 11/2/2026

ketamineinteractions
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Mapping Endogenous Psychedelic Chemistry: Indolethylamine N -Methyltransferase (INMT) Localizes Proximal to the Golgi Apparatus of Human Neurons

Europe PMC · 11/2/2026

mechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

A multi-institutional investigation of psilocybin's effects on mouse behavior.

Europe PMC · 11/2/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

From Evidence to Practice: A Systematic Review of Implementation of Psychedelic-Assisted Psychotherapy.

Europe PMC · 11/2/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Impact of Histopathology and Bladder Dysfunction on the Treatment Strategy Selection of Ketamine-Associated Cystitis.

Europe PMC · 11/1/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Chronic Mild Stress in Male Wistar-Kyoto Rats Induces Long-Term Hippocampal Plasticity Impairments Differentially Reversed by Acute and Chronic Ketamine Treatment.

Europe PMC · 11/1/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

The ketamine bladder.

Europe PMC · 11/1/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
policy-law
submitted

Patient Safety and Regulatory Transparency on Ketamine Clinic Websites in South Florida: A Cross-Sectional Audit.

Europe PMC · 11/1/2026

ketaminesafetypolicy-law
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Oral Ketamine Adjunct for Wound Care in Patients With Burn Injuries.

Europe PMC · 11/1/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Furthering the Understanding of Psilocybin Use and Molecules Relevant to Depression and Schizophrenia.

Europe PMC · 11/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psilocybin Use in Psychiatry: Clinical Practice and Public Health Implications.

Europe PMC · 11/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

How Psilocybin Alters Consciousness: Psychedelics can create a "hidden order" in brain activity that could explain how these drugs affect our sense of self.

Europe PMC · 11/1/2026

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Changes in self-related cognitive processes and depressive symptom severity following a single, moderate dose of psilocybin in depressed patients.

Europe PMC · 11/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Researchers' Experiences with IRB Oversight of Psychedelic Research.

Europe PMC · 11/1/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psychedelic ego-dissolution: a philosophical and qualitative critique.

Europe PMC · 11/1/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Next-Generation Psychedelic Drug Development.

Europe PMC · 11/1/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Retraction: 17β-Estradiol protects neural stem/progenitor cells against ketamine-induced injury through estrogen receptor β pathway

Europe PMC · 10/31/2026

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

MDMA-assisted therapy for veterans with comorbid posttraumatic stress disorder and alcohol use disorder: Clinical outcomes from the first open-label pilot trial.

Europe PMC · 10/30/2026

mdmaclinical-evidenceveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
safety-study
submitted

The Fireside Database: Large-scale evidence from 25,419 psychedelic support interactions.

Europe PMC · 10/30/2026

interactions
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Effects of psilocybin with psychological support on anhedonia in treatment-resistant depression: A randomized controlled pilot trial.

Europe PMC · 10/30/2026

psilocybinclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
safety-study
submitted

The Fireside Database: Large-scale evidence from 25,419 psychedelic support interactions

Europe PMC · 10/30/2026

interactions
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Post-psychedelic and meditation-related challenges: a protocol for a mixed-methods longitudinal-observational study

medRxiv · 10/29/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

Exploring the durability of esketamine and ketamine's antidepressant effects in the maintenance phase of treatment: A systematic review.

Europe PMC · 10/29/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Neuroprotective activity of sub-anesthetic ketamine in a preclinical model of Parkinson’s disease is not blocked by antagonizing brain-derived neurotrophic factor signaling

Europe PMC · 10/29/2026

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Multi-scale effects of single-dose psilocybin in the macaque brain

Europe PMC · 10/29/2026

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin, cognitive stability and drinking reduction in co-occurring alcohol use disorder and depression: a pilot secondary analysis of a randomized, placebo-controlled trial

Europe PMC · 10/29/2026

psilocybinclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

A portable voltammetric sensor for presumptive screening of xylazine and ketamine in spiked beverages.

Europe PMC · 10/28/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

The photostability of ketamine products: part ii impact of light exposure and storage on multi-use ketamine parenteral products.

Europe PMC · 10/28/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Effects of Bolus Versus Infusion Ketamine During Laparoscopic Cholecystectomy

Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital · 10/28/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Item-Level Symptom Trajectories Across the PHQ-9 During At-Home Ketamine-Assisted Therapy for Depression: A Real-World Retrospective Analysis of 36,847 Adults

Europe PMC · 10/27/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Magic pathways: the genes and enzymes of psilocybin biosynthesis.

Europe PMC · 10/27/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Independent evolution of harmala alkaloids in medicinal Syrian rue and ayahuasca plants

Europe PMC · 10/27/2026

ayahuasca
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Adapted Massed Exposure Therapy Enhanced with MDMA for PTSD (aMETEMP): A randomized, double-masked protocol adapted for Veterans Affairs healthcare system.

Europe PMC · 10/27/2026

mdmaclinical-evidenceveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Temporal trends and clinical factors associated with ketamine infusion in hospitalized infants with bronchopulmonary dysplasia.

Europe PMC · 10/26/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Evaluating whether a therapeutic dose of ketamine exposure during adolescence influences adult vulnerability in rats to commonly abused drugs.

Europe PMC · 10/26/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Low-dose ketamine modulates brain entropy in treatment-resistant depression: Results from two neuroimaging clinical trials.

Europe PMC · 10/26/2026

ketamineclinical-evidencemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Single Intranasal Administration of the Psychedelic Mebufotenin for Treatment-Resistant Depression: A Randomized Clinical Trial.

Europe PMC · 10/26/2026

clinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Sex-related differences in outcomes following psilocybin or escitalopram: a Bayesian secondary analysis.

Europe PMC · 10/26/2026

psilocybinclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Effects of Different Doses of Ayahuasca on Personality in Healthy Volunteers

University of Sao Paulo · 10/26/2026

ayahuasca
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

From Acute MDMA Experiences to Lasting Change: Self-Compassion’s Role in MDMA-Assisted Psychotherapy for Social Anxiety Disorder

Europe PMC · 10/25/2026

mdma
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Intercultural pathways to indigenous mental health: the integration of ayahuasca in community care in the Yaqui intercultural medicine clinic in Sonora, Mexico

Europe PMC · 10/24/2026

ayahuascaintegration
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Role of Ventral Tegmental Area Dopamine Neurons in Emergence from Dexmedetomidine, Fentanyl, and Ketamine Anesthesia in Rats.

Europe PMC · 10/23/2026

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine Beyond Anaesthesia: Analgesic, Psychiatric, Antitumour, and Immunomodulatory Actions and Their Signalling Mechanisms.

Europe PMC · 10/23/2026

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Dexametedomidine Ketamine Infusion Versus Dexametedomidine Propofol Infusion in Non-compliant Agitated Patients on Continuous Positive Airway Pressure (CPAP) Mask Ventilation in the Intensive Care Unit

Ain Shams University · 10/22/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

A ketamine derivative exerts enhanced antidepressant effects via adenosine signaling.

Europe PMC · 10/22/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Effects of remifentanil/ketamine mixtures in rats responding under a choice procedure.

Europe PMC · 10/22/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine Versus Electroconvulsive Therapy for Nonpsychotic Treatment-Resistant Depression: A Cost-Effectiveness Analysis.

Europe PMC · 10/22/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine as an Opioid-Sparing Adjunct During Mechanical Ventilation: Feasible and Ready for a Larger Trial.

Europe PMC · 10/21/2026

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
case-report
submitted

Anesthesia Considerations for Transfemoral Osseointegration in a Patient With CRPS, Propofol, and Ketamine Allergies: A Case Report.

Europe PMC · 10/21/2026

ketamineintegration
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Rapid antidepressant effects of ketamine combined with selective serotonin reuptake inhibitors: Mechanisms and outlook.

Europe PMC · 10/21/2026

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Drug exposure during oxycodone–S-ketamine patient-controlled analgesia reflects pain-related dosing behaviour after lumbar fusion surgery

Europe PMC · 10/21/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Chronic High-Dose Ketamine Fails to Induce a Cystitis-Like Phenotype in Mice Despite High Urinary Metabolite Levels.

Europe PMC · 10/21/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Suicidality during intranasal (es)ketamine treatment: A retrospective cohort study.

Europe PMC · 10/21/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin and Inflammatory and Mitochondrial Stress Markers in Parkinson Disease: A Nonrandomized Clinical Trial.

Europe PMC · 10/21/2026

psilocybinclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Repeated ketamine administration induces cross-tolerance to sodium salicylate but not to morphine in male rats.

Europe PMC · 10/20/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Beyond Symptom Reduction: Interconnectedness and Self-Transcendent Emotions During MDMA Sessions Predict Flourishing, Not Symptom Change, in Social Anxiety Disorder Treatment

Europe PMC · 10/20/2026

mdma
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Buprenorphine After Ketamine for Suicidal Ideation: Durability, Specificity, and Confounding.

Europe PMC · 10/19/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Buprenorphine Following Ketamine for Suicidal Ideation: A Bridge to Care from the Emergency Department.

Europe PMC · 10/19/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Low-Dose Buprenorphine Significantly Prolonging the Antisuicidal Effects of Ketamine Infusion in Major Depressive Disorder: Relationship Between Antidepressant and Antisuicidal Effects.

Europe PMC · 10/19/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Low-Dose Buprenorphine Following Ketamine Treatment for Suicidal Ideation in Major Depressive Disorder: Response to Letters.

Europe PMC · 10/19/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine Extension or Buprenorphine Maintenance?

Europe PMC · 10/19/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Subanesthetic ketamine modulates region-specific neural and endocrine responses to acute stress in rats.

Europe PMC · 10/19/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Neural correlates of ketamine-induced dilation of temporal expectation

Europe PMC · 10/19/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
meta-analysis
submitted

Efficacy and Safety of Etomidate Versus Ketamine for Endotracheal Intubation in Critically Ill Patients: A Systematic Review and Meta-Analysis

Europe PMC · 10/19/2026

ketaminesafetyclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

Ketamine in psychiatry: a systematic review of clinical applications, safety considerations, and emerging challenges

Europe PMC · 10/19/2026

ketaminesafety
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine Infusion Protocol for the Treatment of Complex Regional Pain Syndrome

Europe PMC · 10/19/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Investigation of the pharmacological and circuit basis for psychedelic drug effects on interval timing in mice.

Europe PMC · 10/19/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

Psilocybin for anhedonia in unipolar and bipolar depression: A systematic review of clinical and preclinical evidence.

Europe PMC · 10/19/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Evaluation of the Effects of Different Doses of Ayahuasca on Intelligence and Verbal Memory in Healthy Volunteers: A Preliminary, Exploratory, Double-Blind, Randomized, Placebo-controlled Study.

Europe PMC · 10/19/2026

ayahuascaclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Bridging Suicidal Crisis to Outpatient Care: Could Ketamine Plus Buprenorphine Shift the Paradigm?

Europe PMC · 10/19/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

[Integrated use of ketamine in emergency care].

Europe PMC · 10/18/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine administration reduced conditioned defensive behaviour and upregulated protein expression associated with neuroplasticity in a planarian model of aversive memory reactivation.

Europe PMC · 10/17/2026

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Serotonin 1B receptors expressed on forebrain excitatory neurons mediate the post-acute anxiolytic response to psilocybin in mice.

Europe PMC · 10/17/2026

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
meta-analysis
submitted

Effects of Ketamine and Esketamine on Postoperative Delirium After General Anesthesia: A Meta-Analysis and Meta-Regression Analysis.

Europe PMC · 10/16/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
meta-analysis
submitted

Safety, efficacy, and opioid-sparing effects of ketamine for analgesia in traumatic chest injury and rib fractures: a systematic review and meta-analysis

Europe PMC · 10/16/2026

ketaminesafetyclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Comparative chromosome-scale genomics of the ayahuasca liana Banisteriopsis caapi reveals paleopolyploid ancestry and recent tandem-gene expansions as candidate signatures of ethnovariety differentiation

Europe PMC · 10/16/2026

ayahuasca
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Context Shapes Alpha-Band Electrophysiological Signatures under Psilocybin

Europe PMC · 10/16/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
case-report
submitted

Correction: Sustained abstinence in severe ketamine use disorder following ibogaine treatment case report

Europe PMC · 10/16/2026

ibogaineibogaketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Stroboscopic light stimulation as a controllable probe of the psilocybin state: a mechanistic framework and a falsifiable prediction

Europe PMC · 10/16/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Studying the Molecule, Assuming the Experience: The Pharmacology–Experience Asymmetry Framework for Psychedelic Research

Europe PMC · 10/16/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Longitudinal peripheral DNA methylation remodeling following ketamine-assisted psychotherapy in major depressive disorder.

Europe PMC · 10/15/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Comparable Acute Antidepressant-like Effects of Two Subanesthetic Ketamine Doses Are Associated with Divergent Region-Specific Molecular Responses After Adolescent Chronic Stress.

Europe PMC · 10/15/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

5-HT<sub>2A</sub> receptors in layer 5 pyramidal neurons mediate the neuroplastic but not the hallucinogenic effects of psilocybin.

Europe PMC · 10/15/2026

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Safety and efficacy of psilocybin-assisted therapy for alcohol use disorder: Open-label extension of a phase II randomized controlled trial.

Europe PMC · 10/15/2026

psilocybinsafetyclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

A longitudinal analysis of the clinical practice of ketamine assisted psychotherapy with adolescents and young adults

Europe PMC · 10/7/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

Ketamine use in the refractory and super refractory status epilepticus: a systematic review

Europe PMC · 10/6/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

Comparison of propofol fentanyl versus propofol ketamine for painless gastrointestinal endoscopy: a systematic review

Europe PMC · 10/6/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Dose-dependent modulation of visual imagery by Ayahuasca and dampening of visual processing away from external input: a placebo-controlled pharmacoimaging study

Europe PMC · 10/5/2026

ayahuasca
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

An Open-Label Multidose Psilocybin Intervention for Obsessive-Compulsive Disorder.

Europe PMC · 10/5/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Therapists’ Perspectives on the Psychotherapeutic Support in Psilocybin Treatment for Major Depressive Disorder: Insights from a Randomized Controlled Trial

Europe PMC · 10/5/2026

psilocybinclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous Nephrolithotomy

Assiut University · 10/2/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Effects of Repeated Ketamine Infusions on Suicidal Ideation in Treatment-Resistant Depression and Associated Changes in Selected Plasma Biomarkers.

Europe PMC · 10/2/2026

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Through the PRISM: Reinterpreting Psychedelic Cognition as Motivational Reallocation

Europe PMC · 10/2/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Extracellular flux analysis and proteomic profiling indicate ibogaine promotes synaptic plasticity and neural repair by a metabolic preconditioning mechanism

Europe PMC · 10/2/2026

ibogaineibogamechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Effects of Psilocybin on Craving in Nicotine Dependence

University of British Columbia · 10/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Evaluation of Sedative and Physiological Effects of Intramuscular or Intranasal Ketamine-Midazolam and Ketamine-Dexmedetomidine in Capuchin Monkeys (Sapajus sp.).

Europe PMC · 10/1/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Risks from self-medicating with psychedelic drugs.

Europe PMC · 10/1/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
safety-study
submitted

Oregon’s State-Regulated Psilocybin Services: Early Real-World Safety Signals

Europe PMC · 10/1/2026

psilocybinsafety
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Large-Scale and Local Functional Connectivity Changes following Psilocybin Administration in Methamphetamine Use Disorder.

Europe PMC · 10/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Embeddedness under psilocybin.

Europe PMC · 10/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Comparison of arterial blood pressure and quality of induction and recovery in horses anesthetized with diazepam or guaifenesin co-induction combined with xylazine and ketamine and maintained on isoflurane.

Europe PMC · 10/1/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Multi-center, randomized controlled efficacy and comparative-effectiveness study evaluating ketamine, stellate ganglion blocks, combination treatment, and sham treatments for posttraumatic stress disorder and traumatic brain injury-associated headache: a study protocol.

Europe PMC · 10/1/2026

ketamineclinical-evidencemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Cognitive and Pyroptotic Outcomes of Neonatal Ketamine and Dexmedetomidine: Potential Neuroprotection via Caspase-1 Modulation.

Europe PMC · 10/1/2026

ketamineclinical-evidencemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ayahuasca treatment reduces 50-kHz ultrasonic vocalizations and modifies mesocorticolimbic monoamine neurochemistry in rats.

Europe PMC · 9/30/2026

ayahuascamechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Mechanisms of anti-depressant and anti- alcohol effects of ketamine in patients with alcohol use disorder

Europe PMC · 9/30/2026

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
case-report
submitted

Worsening of Depression and Anxiety With Psilocybin: A Case Report in Cyclothymia.

Europe PMC · 9/30/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

Comment on "Urological symptoms following ketamine treatment for psychiatric disorders: A systematic review".

Europe PMC · 9/29/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Characterization of Ketamine-Induced Neurotoxicity in PND7 Rats as a Model of Pediatric Anesthesia.

Europe PMC · 9/29/2026

ketaminesafetymechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Evaluation of the Efficacy and Safety of Multimodal Sedation with Dexmedetomidine and Ketamine (Ketodex) at Different Ratios: A Randomized Clinical Trial

Europe PMC · 9/29/2026

ketaminesafetyclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Reduced egocentricity after psilocybin in patients with alcohol use disorder: a pilot randomized controlled trial

Europe PMC · 9/29/2026

psilocybinclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Multimodal predictors of response to intravenous ketamine in treatment-resistant depression: toward personalized treatment in major depressive and bipolar disorders.

Europe PMC · 9/28/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

No Heavy Drinking Days and Percentage of Days Abstinent in a Randomized Trial of Adjunctive Ketamine for Alcohol Use Disorder: Secondary Analysis of the KARE Trial

Europe PMC · 9/28/2026

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Ketamine Alters Tuning of Neural and Behavioral Spatial Working Memory Precision.

Europe PMC · 9/28/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Symptom-level and network analyses of ketamine treatment in treatment-resistant depression: A pooled analysis of two randomized controlled trials.

Europe PMC · 9/26/2026

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Letter to the Editor for "Evaluating Pharmacogenomic Prescription Data in the Military Health System": Medication-Induced CYP2D6 Inhibition Reveals a Screening Gap in Proxy-Defined Ibogaine Candidates.

Europe PMC · 9/26/2026

ibogaineibogainteractionsveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
safety-study
submitted

Ketamine-enhanced psychotherapy for smoking cessation: A pilot study of feasibility, safety, and clinical outcomes.

Europe PMC · 9/25/2026

ketaminesafetyclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Comparison of ketamine versus lignocaine intravenous infusion in refractory cancer pain: a prospective randomised double-blind controlled study.

Europe PMC · 9/25/2026

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

A Study Comparing Oral Ketamine With Oral Midazolam for the Treatment of Major Depressive Episodes

Jawaharlal Institute of Postgraduate Medical Education & Research · 9/24/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Unveiling ayahuasca: Comprehensive Study of Botanical and Chemical Diversity.

Europe PMC · 9/24/2026

ayahuasca
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Intraoperative Ketamine and Chronic Opioid Use After Lumbar Spine Surgery in Patients With and Without Opioid-Use Disorder: A Retrospective Database Analysis.

Europe PMC · 9/23/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Real-World Therapeutic Use of Ketamine in Clinical and Non-Clinical Settings: A Cross-Sectional Survey.

Europe PMC · 9/23/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Psilocybin and Contrasting Musical Compositions: Effects on Music-Evoked Emotional Responses in Healthy Adults

Europe PMC · 9/23/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

5-HT2A receptor activation is dispensable for psilocybin-induced fear extinction and neuroplasticity in mice.

Europe PMC · 9/15/2026

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Implications of Potential US FDA Approval of Psychedelics or Psychedelic-Adjacents Such as Ibogaine for Pharmacy in Japan

Europe PMC · 9/14/2026

ibogaineiboga
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Therapeutic Alliance and Perceived Closeness in MDMA-Assisted Therapy for Social Anxiety Disorder

Europe PMC · 9/11/2026

mdma
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Characterizing Psychedelic-Evoked Familiarity: A Comparative Study with Autobiographical and Déjà Vu Experiences.

Europe PMC · 9/11/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

MDMA administration reduces ethanol drinking and is associated with altered nociceptin and dynorphin system gene expression in alcohol-preferring rats.

Europe PMC · 9/11/2026

mdma
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psilocybin.

Europe PMC · 9/10/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psilocybin restores spatial memory but not fronto-hippocampal synchrony in a rat model of Alzheimer's disease.

Europe PMC · 9/10/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

What Is Psilocybin?

Europe PMC · 9/10/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psychedelic 4-AcO-DMT attenuated looming-induced freezing behaviors by activating PrL <sup>CaMKIIα</sup> neurons in mice.

Europe PMC · 9/9/2026

dmtmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
meta-analysis
submitted

MDMA-Assisted Therapy May Decrease PTSD Symptoms, Dissociation, Depression, and Functional Disability: A Systematic Review and Meta-Analysis.

Europe PMC · 9/9/2026

mdmaveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Craving Reduction and Smoking Outcomes in Psilocybin-Assisted and Standard Cessation Care.

Europe PMC · 9/9/2026

psilocybinclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psilocybin selectively suppresses novelty-induced grooming via 5-HT2B receptors: A microstructure analysis in Wistar rats.

Europe PMC · 9/9/2026

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

A Two-Threshold Model of Psilocybin Response Explains Variability in Psychedelic-Assisted Therapy for Treatment-Resistant Depression

Europe PMC · 9/9/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Higher signal diversity, network dysregulation, and increased well-being under DMT administration: An EEG study.

Europe PMC · 9/7/2026

dmt
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

Who Is Reached by Supervised Psilocybin Services? Oregon Services Versus National Psilocybin Use

Europe PMC · 9/7/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Exploratory Insights into 5-MeO-DMT Experiences on Reddit: A Thematic Analysis.

Europe PMC · 9/7/2026

5-meo-dmtdmt
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psilocybin as an emerging anxiolytic: mechanisms, evidence, and open questions.

Europe PMC · 9/6/2026

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psychedelic Renaissance: A New Paradigm in Mental Health

Europe PMC · 9/4/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
meta-analysis
submitted

Electroconvulsive Therapy vs. Ketamine: A Scoping Review and Meta-Analysis of Rapid-Acting Interventions for Acute Suicidality in Adults

Europe PMC · 9/4/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Daily briefing: Psilocybin blocks side-effect of chemotherapy in mice.

Europe PMC · 9/4/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psilocybin-induced changes in electroencephalography link acute and long-term effects.

Europe PMC · 9/4/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

One dose of Psilocybin modulates Brain Activity among Depressive patients : Preliminary Neuroimaging Results from the PSILODAC Study

Europe PMC · 9/4/2026

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Electroconvulsive Therapy and (Es)Ketamine in Treatment-Resistant Depression: A Review of Current Evidence

Europe PMC · 9/4/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

The use of ketamine in the management of suicidal crisis: a literature review

Europe PMC · 9/4/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Longitudinal Assessment of Ketamine-Assisted Community of Practice Therapy: A Retrospective 5-Year Study on Depression, Anxiety and PTSD

Europe PMC · 9/4/2026

ketamineveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Clinical Outcomes of Ketamine Therapy for Depression, Anxiety, and PTSD in Post-TBI Patients

Europe PMC · 9/4/2026

ketamineclinical-evidenceveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

The effect of the Apollo Neuro device on anxiety among participants who underwent ketamine assisted therapy: A non-randomized, observational cohort study

Europe PMC · 9/4/2026

ketamineclinical-evidencemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Exploring Attitudes Toward MDMA-Assisted Therapy in Mental Health Care

Europe PMC · 9/4/2026

mdma
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

MDMA-Assisted Psychotherapy for Cluster B Personality Disorders: A Narrative Review of This Translational Framework for Relational Healing

Europe PMC · 9/4/2026

mdma
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

The therapeutic potential of psychedelic drugs: past, present, and future

Europe PMC · 9/4/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Boundaries or boundlessness? Toward knowledge co-creation in psychedelic-assisted therapy

Europe PMC · 9/4/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

A Molecule-Resolved Bibliometric Analysis of PubMed-Indexed Psychedelic Research (2015–2025): Volume, Temporal Trends, and Publication Types

Europe PMC · 9/4/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
policy-law
submitted

No more harm: A guiding principle of psychedelic drug policy

Europe PMC · 9/4/2026

policy-law
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Long-term maintenance therapy with ketamine infusions for treatment-resistant depression: a retrospective chart review

Europe PMC · 9/4/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Behavioural Activation Therapy and Ketamine for Treatment-Resistant Depression

The Royal's Institute of Mental Health Research · 9/3/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Effectiveness of IV Ketamine Therapy in the Management of Treatment Resistant Depression

Europe PMC · 9/3/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
case-report
submitted

Successful Management Of Refractory Precipitated Opioid Withdrawal Syndrome Following Buprenorphine Intake Using Ketamine: A Case Report

Europe PMC · 9/3/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation.

Europe PMC · 9/3/2026

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
case-report
submitted

Ketamine Addiction With Multisystem Toxicity: A Case Report From Canon Lan Detox Unit, Neath Port Talbot Hospital, South Wales

Europe PMC · 9/3/2026

ketaminesafety
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
case-report
submitted

Trial of Subcutaneous Ketamine for Psychotic Depression in an Older Adult With Comorbid Physical Illness: A Case Report

Europe PMC · 9/3/2026

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
preprint
submitted

In Vitro Ketamine Attenuates Immune Sensitization in Major Depressive Disorder in a Concentration-Dependent Manner

medRxiv · 9/2/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
meta-analysis
submitted

A response to the letter to editor: Breaking the chains of depression: A systematic review and meta-analysis of psilocybin therapy.

Europe PMC · 9/2/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

805. Rapid Antidepressant-Like Effects of 5-MeO-DMT Require Both 5-HT1A and 5-HT2A Receptors

Europe PMC · 9/1/2026

5-meo-dmtdmtmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

444. In depth behavioral phenotyping of sex-dependent consequences of maternal separation in mice and effects of psilocybin

Europe PMC · 9/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

469. The serotonin 5-HT2A agonist psilocybin in the treatment of neuropathic pain

Europe PMC · 9/1/2026

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

562. Repeated psilocybin administration does not induce rewarding effects and increases ventral tegmental dopaminergic activity during withdrawal

Europe PMC · 9/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Factors Associated with Intentions to Use Psilocybin for Mental Health in Relation to Psychotherapy, Psychiatric Medications, and Natural/Synthetic Options.

Europe PMC · 9/1/2026

psilocybininteractions
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

433. Psilocybin reveals diverse antidepressant efficacies across different preclinical models of depression

Europe PMC · 9/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
safety-study
submitted

701. Efficacy and safety of COMP360 psilocybin therapy in anorexia nervosa: a proof-of-concept study

Europe PMC · 9/1/2026

psilocybinsafetyclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

Psilocybin, From Ancestral Use to Therapeutic Potential: A Multidimensional Review of Its Pharmacological Basis and Current Perspectives.

Europe PMC · 9/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

263. Feasibility of psilocybin treatment in Japanese patients with treatment-resistant depression: an open-label study

Europe PMC · 9/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

354. Effects of psilocybin treatment on cognitive function in Japanese patients with treatment-resistant depression: an open-label study

Europe PMC · 9/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

643. A mechanism-informed clinical trial of psilocybin-assisted therapy for opioid use disorder: rationale and neurobiological framework

Europe PMC · 9/1/2026

psilocybinclinical-evidencemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

475. Psilocin pharmacokinetics and exposure-response relationships in Japanese patients with treatment-resistant depression receiving psilocybin therapy: an open-label study

Europe PMC · 9/1/2026

psilocybininteractions
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

429. Association between subjective experiences and symptom improvement following psilocybin therapy in Japanese patients with treatment-resistant depression: an open-label study

Europe PMC · 9/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

706. Neurobiology of MDMA and mechanisms in trauma recovery

Europe PMC · 9/1/2026

mdmamechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

530. Detecting neuroplastic effects induced by ketamine and classic psychedelics in healthy human subjects

Europe PMC · 9/1/2026

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

717. Clinical trials, ethical dimensions, and the pathway of MDMA-assisted therapy in PTSD

Europe PMC · 9/1/2026

mdmaclinical-evidenceveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

252. Clinical application of psychedelic-assisted therapy in major depression and addictions

Europe PMC · 9/1/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
systematic-review
submitted

846. Inconsistent trial risk-of-bias judgements across psychedelic-assisted psychotherapy systematic reviews

Europe PMC · 9/1/2026

clinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

188. A single high-dose acute injection of 5-MeO-DMT reverses stress-induced anhedonia in rats

Europe PMC · 9/1/2026

5-meo-dmtdmt
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research-article
submitted

515. Influence of the context of administration on 5-MeO-DMT-promoted antidepressant-like effects and neuroplasticity

Europe PMC · 9/1/2026

5-meo-dmtdmtmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

THIS STUDY AIMS TO COMPARE TWO DRUGS KETAMINE AND TRAMAL IN PREVENTION OF SHIVERING IN PATIENTS UNDERGOING SPINAL ANESTHESIA STUDY POPULATION IS PT UNDERGOING C SECTION . DOSE OF KETAMINE IS 0.25mg/kg and That of TRAMAL 0.5mg/kg.

KRL Hospital, Islamabad · 8/25/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Intravenous Infusion of Low Dose Ketamine Versus Dexmedetomedine for Delirium Treatment in Acute Heart Failure

Alexandria University · 8/24/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

MDMA-AT for PTSD in Young Adults With Childhood Trauma

Mclean Hospital · 8/14/2026

mdmaveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Psychedelic Safety and Clinical Outcomes Across Exposure Patterns: A Structured Narrative Review.

Life (Basel) · 8/14/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Testing Two Doses of Nebulized Ketamine for Postoperative Sore Throat

Aswan University Hospital · 8/4/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Nebulized Lidocaine And Ketamine Before Fiberoptic Bronchoscopy

Alexandria University · 8/3/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Inhalable Psychedelic 5-MeO-DMT Shows Promise in Treatment-Resistant Depression.

J Med Chem · 8/1/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin-Assisted Group Integration Psychotherapy for Treatment-Resistant Depression

University Health Network, Toronto · 7/30/2026

psilocybinintegration
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Trauma-informed Psilocybin Assisted Psychotherapy (TiPAP) for PTSD

Tel-Aviv Sourasky Medical Center · 7/30/2026

psilocybinveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Nebulized Ketamine for Severe Asthma Attacks in Children

Sultan Qaboos University · 7/27/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin

National Institutes of Health Clinical Center (CC) · 7/23/2026

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life

Vail Health Behavioral Health · 7/22/2026

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Assessing Covert Consciousness During Dexmedetomidine and Ketamine Sedation: An fMRI Study

University of Michigan · 7/15/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Working Mechanisms and Effectiveness of IV Ketamine-assisted Psychotherapy on Depression in TRD Clients

Senz · 7/15/2026

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Neural Effects of Intravenous N,N-dimethyltryptamine (DMT)

University of California, San Diego · 7/9/2026

dmt
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Psychedelics and Ibogaine "Pain Medications" at the Pharmacy Counter: Implications for Pharmacy Practice.

J Pain Res · 7/8/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Low Dose Bolus Ketamine For Use In Sickle Cell Pain Crisis

University of Mississippi Medical Center · 7/6/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Intraperitoneal Ketamine Versus Fentanyl as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy

Assiut University · 6/26/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

U.S. Psychedelic Use and Microdosing in 2025: Insights from a Probability-Based and Nationally Representative Survey.

Rand Health Q · 6/26/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Mechanistic insights toward dissociating therapeutic from psychedelic effects: bridging the gap between psychedelic research and mental health care.

Transl Psychiatry · 6/24/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Efficacy in Relapse Prevention: Psilocybin in Alcohol Use Disorder With Depressive Symptoms

Centre Hospitalier Universitaire de Nīmes · 6/10/2026

psilocybinclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Psychedelic-Assisted Interventions in Palliative Care: A Narrative Overview and Critical Evaluation.

Healthcare (Basel) · 6/2/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

A systematic review of the pharmacokinetics of classical serotonergic psychedelic compounds in healthy adult subjects.

J Psychopharmacol · 5/29/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin Efficacy With or Without Pimavanserin Pretreatment

Johns Hopkins University · 5/27/2026

psilocybinclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Overcoming Pharmacokinetic and Peripheral Safety Challenges in Psychedelic Therapies: The Promise of Advanced Drug Delivery Systems.

ACS Pharmacol Transl Sci · 5/25/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine Added to Quadratus Lumborum Block for Pain Relief After Infant Pyeloplasty

Alexandria University · 5/19/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

KetAmine and Recovery After Mechanical VentilAtion ( KARMA )

Assistance Publique - Hôpitaux de Paris · 5/15/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

MDMA Therapy in Veterans With PTSD

Sunstone Medical · 5/6/2026

mdmaveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

Massachusetts General Hospital · 5/4/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and Symptoms of Depression

University of Washington · 5/4/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Oropharyngeoesophageal Topical Anesthesia Versus Intravenous Propofol -Ketamine Sedation for Upper Gastrointestinal Endoscopy

Zagazig University · 5/1/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine Gargle for Pain After Pediatric Tonsillectomy

Hospital Universitario de Caracas · 4/30/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Secular Mysticism: Entanglements of Science and Religion in Psychedelic Medicine.

Cult Med Psychiatry · 4/29/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Comparison of Two Drugs ,i.e., Nalbuphine Vs Ketamine at Low Doses for the Peri-Operative Shivering Control in Patients Undergoing Gynaecological Surgery Under Spinal Anaesthesia

Sargodha Medical College · 4/22/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

MDMA Assisted Therapy for BN

Icahn School of Medicine at Mount Sinai · 4/21/2026

mdma
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Psychedelic-Assisted Therapy For Death Acceptance in Terminal Illness: A Scoping Review.

J Psychedelic Stud · 4/15/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Efficacy of N, N-dimethyltryptamine (DMT) psychedelic therapy for substance misuse: A systematic review and meta-analysis.

J Psychopharmacol · 4/12/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Comparison of Combined Dexmedetomidine and Ketamine (Ketodex) Versus Dexmedetomidine Alone in Awake Mapping for Deep Brain Stimulation: A Randomized Controlled Trial

Ain Shams University · 4/7/2026

ketamineclinical-evidencemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Psychedelic-assisted pharmacotherapy: clinical applications and regulatory considerations.

Expert Opin Pharmacother · 4/7/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder

University of New Mexico · 4/1/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Psychedelic exposure in pregnancy: a scoping review to inform perinatal drug safety and clinical counseling.

Ther Adv Drug Saf · 3/31/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery

Bursa City Hospital · 3/24/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Study of Psilocybin Under Anesthesia Controlled by EEG

Stanford University · 3/18/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

KF2025#1 Trial: Ketamine, Cannabidiol and Cobicistat Interaction Study

Helsinki University Central Hospital · 3/10/2026

ketamineinteractionsclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Psychedelic therapy and postpartum depression: priorities and prospects.

Ther Adv Psychopharmacol · 3/9/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Confronting mortality: A meta-analysis and systematic review of psychedelic experiences and death anxiety.

J Psychopharmacol · 3/9/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin Microdosing on Cognition, Mood and Quality of Life

Yale University · 3/4/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Optimal Timing of Ketamine Initiation for SCD Pain

Boston Children's Hospital · 3/4/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Acute Effects of Intravenous 5-MeO-DMT in Healthy Participants

University Hospital, Basel, Switzerland · 3/3/2026

5-meo-dmtdmt
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Ayahuasca and Its Main Component <i>N,N</i>-Dimethyltryptamine (DMT) for the Treatment of Mental Disorders: Mechanisms of Action, Clinical Studies, and Tools to Explore the Human Mind.

Biomedicines · 2/25/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine for Shoulder Pain Following Laparoscopic Gastric Sleeve Surgery

King Abdullah University Hospital · 2/24/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin After Trauma Surgery for Pain

University of Pittsburgh · 2/12/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Mitochondrial Function After Ketamine

Sheba Medical Center · 2/10/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

A Clinical Trial of Add-on Oral Slow-release Ketamine Treatment in Major Depression

Region Skane · 2/9/2026

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat

Sohag University · 2/2/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Psychedelic- and Substance-Assisted Therapies in Global Mental Health: Bridging Cultures, Evidence, and Access.

Brain Behav · 2/1/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Understanding Music and Mindfulness Preferences in Psilocybin-Assisted Psychotherapy

Sir Mortimer B. Davis - Jewish General Hospital · 1/28/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery Enhancement

University of California, San Diego · 1/27/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Intravenous Lidocaine, Ketamine, and Magnesium in Thoracic Surgery

Universidad Pública de Navarra · 1/22/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Salivary Oxytocin as a Biomarker of Psychedelic Treatment

University of Geneva, Switzerland · 1/16/2026

mechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft Surgery

University Medical Centre Ljubljana · 1/14/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin-Assisted Therapy

Emory University · 1/12/2026

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Comparison of Intravenous Ondansetron and Low Dose Ketamine in Preventing Post Spinal Shivering

Mayo Hospital Lahore · 1/12/2026

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Determination and Confirmation of Psychedelic and Psychoactive Compounds in Botanical Materials by UPLC-ESI-MS/MS: Single-Laboratory Validation.

J AOAC Int · 1/1/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine Biomarker Validation

Soterix Medical · 12/29/2025

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

The CAnadian Network for Psychedelic-Assisted Cancer Therapy (CAN-PACT): A Multi-Phase Program Overview.

Curr Oncol · 12/22/2025

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Predictors of therapeutic response to psychedelic-assisted therapy: A systematic review.

J Psychopharmacol · 12/13/2025

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Clinical Trial Exploring the Outpatient Treatment of Phantom Limb Pain With Ketamine Administration in a Six Month Study With a Minimum Remission Period of 7 Days Between Treatment Session. 25-30 Subjects With an Ongoing History of Significant PLP.--FDA and IRB Approved.

The Ketamine Research Foundation · 12/11/2025

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Safety and Preliminary Efficacy of Organic Whole Psilocybin-Containing Mushrooms to Treat Patients Suffering From PTSD

Scottsdale Research Institute · 12/10/2025

psilocybinsafetyclinical-evidenceveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin to Treat Depression in Spinal Cord Injury

James J. Peters Veterans Affairs Medical Center · 11/26/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression

University of Rochester · 11/25/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community.

Harm Reduct J · 11/25/2025

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Psychedelic Augmentation of 12-Step Engagement: A Novel, Accessible Approach to Enhance Community-Based Recovery from Substance Use Disorders.

J Psychoactive Drugs · 11/10/2025

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Sedative and Analgesic Effects of Dexmedetomidine Versus Ketamine in Patients Undergoing Varicocelectomy Under Spinal Anaesthesia: A Prospective Randomized Comparative Trial

Assiut University · 10/9/2025

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression

Centre for Addiction and Mental Health · 10/8/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Dexmedetomidine vs Ketamine as Adjuvants to Bupivacaine in Transversus Abdominus Plane Block in Inguinal Hernioplasty

Ain Shams University · 9/26/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Efficacy of Propofol Combination With Either Ketamine, Dexmedetomidine or Midazolam for Sedation During Upper Gastrointestinal Endoscopic Procedures

Ain Shams University · 9/24/2025

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Observational Pilot Study to Explore the Social and Health Impacts of a New Model of Care in Oregon: Psilocybin Services on Alcoholism

Healing Advocacy Fund · 9/24/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine in Central Sensitization

University Hospitals Cleveland Medical Center · 9/19/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery.

Liaquat National Hospital & Medical College · 9/18/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Safety, Therapeutic Potential, and Mechanisms of Two Psilocybin Doses, Administered With Psychological Support in Young Adults With Anorexia Nervosa

Region Skane · 9/12/2025

psilocybinsafetymechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts

New York State Psychiatric Institute · 8/24/2025

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy Pain

Tanta University · 8/24/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin as a Treatment for Chronic Pain in Smokers

Yale University · 8/12/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations

Oman Medical Speciality Board · 8/8/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Mindfulness-based Psilocybin Therapy for PTSD

Ohio State University · 8/5/2025

psilocybinveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

The Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron

Mayo Clinic · 8/5/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

MDMA-Assisted Therapy for Mental Healthcare Providers

Icahn School of Medicine at Mount Sinai · 8/3/2025

mdma
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Chart Review of Patients Undergoing Ketamine Treatments for Depression

Sunnybrook Health Sciences Centre · 8/1/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine Infusion for Symptomatic Improvement in Severe Borderline Personality Disorder

University Hospital, Toulouse · 8/1/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Prehospital Early Administration of Ketamine for Status Epilepticus in Epileptic Kids (PEAK-SEEK)

Sohag University · 7/31/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine Augmentation of ECT in Treatment-Resistant Depression

Università Vita-Salute San Raffaele · 7/28/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Safety and Psychological Effects of Psilocybin and D-Serine Formulation in Healthy Volunteers

Hadassah Medical Organization · 7/23/2025

psilocybinsafety
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin Microdose for Psychological and Existential Distress in Palliative Care (PSYCHED-PAL-RCT)

Bruyère Health Research Institute. · 7/14/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty

State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia · 7/10/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability

Johns Hopkins University · 7/8/2025

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine and Levetiracetam as Second-line Antiseizure Medication for Status Epilepticus in Children

Sohag University · 7/1/2025

ketamineinteractions
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology

CAMC Health System · 6/27/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery

Ain Shams University · 5/29/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Music as an Adjunct to Ketamine Therapy for Chronic Pain

McGill University · 5/29/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin for Treatment of OCD-2

University of Arizona · 5/28/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)

Johns Hopkins University · 5/25/2025

psilocybinmdmaveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin for Chronic Pelvic Pain (CPP) in Women: A Pilot Feasibility Study

Oregon Health and Science University · 5/23/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Dexmedetomidine Versus Dexmedetomidine and Ketamine (Ketodex) in Ear and Nose Surgeries

Sohag University · 5/20/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Sufentanil Versus Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children.

Fondation Lenval · 5/13/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine for Postherpetic Neuralgia With Depression

Huazhong University of Science and Technology · 5/13/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Open Rhinoplasty

Ain Shams University · 5/12/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Evaluation of the Efficacy and Safety of Subcutaneous Ketamine in the Treatment of Depressive Episode With Suicidal Ideation and/or Behavior in Adolescents

Federal University of São Paulo · 5/4/2025

ketaminesafetyclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

A landscape analysis of psychedelic retreat organizations advertising online.

PLoS One · 5/2/2025

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Endometriosis and Pain Treatment by Intraoperative Administration of Low-dose Ketamine

Insel Gruppe AG, University Hospital Bern · 4/30/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Dexmedetomidine Versus Ketamine-midazolam Sedation in Awake Fiberoptic Intubation in Suspected Difficult Airway

Zagazig University · 4/27/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin-Assisted Therapy for Treatment-Resistant Depression in Bipolar II Disorder

University of British Columbia · 4/24/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine and Lidocaine Infusion in Refractory Chronic Migraine

Assiut University · 4/20/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Antidepressant Response of DMT Masked With Propofol

University Hospital, Basel, Switzerland · 4/15/2025

dmt
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Safety and Efficacy of Ketamine Intravenous Infusions in the Treatment of Fibromyalgia

Wilderman Medical Clinic · 4/8/2025

ketaminesafetyclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

Texas Tech University Health Sciences Center · 4/1/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin for Methamphetamine Addiction

Louisiana State University Health Sciences Center Shreveport · 3/28/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence

University of Calgary · 3/20/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning-Based Advanced Perspectives.

Adv Sci (Weinh) · 3/20/2025

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Comparison of Oral Dexmedetomidine, Ketamine Versus Midazolam for Premedication in Children Undergoing Injuinal Surgeries

Tanta University · 3/17/2025

ketamineinteractions
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Reducing Pain With Methadone and Ketamine in Liver Transplant

Lahey Clinic · 3/11/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

ESKetamine Low-dose vs Ketamine Low-dose for Severe Acute Pain in Emergency Units, Comparison of PsychodyslEptic Effects

Centre Hospitalier Universitaire de Nice · 2/28/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin Brain Stimulation and Imaging Pilot Study

Johns Hopkins University · 2/19/2025

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Efficacy of Propofol-Ketamine and Sevoflurane in Children Undergoing Magnetic Resonance Imaging

Kocaeli City Hospital · 2/18/2025

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Evaluating the Neuromodulatory Effect of Ketamine in Long COVID-19

University of Texas at Austin · 2/11/2025

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Psychedelics and chronic pain: self-reported outcomes on changed substance use patterns and health following naturalistic psychedelic use.

Br J Pain · 2/11/2025

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Sustained Ketamine Effectiveness for Suicidal Ideation

University Hospital, Montpellier · 2/4/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Intraperitoneal Ketamine Versus Bupivacaine for Postoperative Pain Control After Laparoscopic Cholecystectomy

Liaquat National Hospital & Medical College · 2/4/2025

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors

M.D. Anderson Cancer Center · 1/30/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

PsiloIMAGINE: A Psychedelic-augmented Mental Imagery-based Intervention for Young People With Self-harm

Imperial College London · 1/29/2025

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Wellcome Leap Psilocybin for OUD

University of Pennsylvania · 1/22/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Investigation of Psychedelic Effects in Psychoactive Substances

Johns Hopkins University · 1/14/2025

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Subjective Experience Following Psilocybin

University of Calgary · 1/10/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS)

NYU Langone Health · 1/7/2025

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

The Impact of Propofol and Ketamine on Cardiovascular Collapse During Induction for Intubation

Kocaeli City Hospital · 12/27/2024

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Effect of Psilocybin Only and Psilocybin Assisted Cognitive Behavioral Therapy in the Management of Major Depressive Disorder and Associated Metabolic, Immune, Inflammatory, Neuroplasticity and Electrical Activity Markers

Khyber Medical University Peshawar · 12/24/2024

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest

Copenhagen University Hospital, Rigshospitalet · 12/20/2024

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Dexmedetomidine Versus Ketamine as Adjuvants in Bariatric Surgery

Tanta University · 12/17/2024

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAIN

Unity Health Toronto · 12/12/2024

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin for Prolonged Grief Disorder

University of Virginia · 12/9/2024

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality

The University of Texas Health Science Center, Houston · 11/26/2024

psilocybinsafety
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Integrating Ketamine Effects on Neuronal Molecular Signatures and the Brain Functional and Structural Connectome

Massachusetts General Hospital · 11/21/2024

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Therapeutic Potential of Psychedelic Compounds for Substance Use Disorders.

Pharmaceuticals (Basel) · 11/5/2024

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Intravenous Ketamine for Treatment-Resistant Depression

Mayo Clinic · 10/31/2024

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis

Johns Hopkins University · 10/24/2024

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Effect of Psilocybin on the Positive Valence System in Treatment-resistant Depression

Centre Hospitalier Universitaire de Nīmes · 10/21/2024

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Evaluation of the Effect of a Single Dose of Psilocybin on Neural Correlates of Cognitive Control in Patients With Psychogenic Nonepileptic Seizures

Centre Hospitalier Universitaire de Nīmes · 10/17/2024

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression

The Cleveland Clinic · 10/1/2024

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
research
submitted

Harnessing Pharmacogenomics in Clinical Research on Psychedelic-Assisted Therapy.

Clin Pharmacol Ther · 9/30/2024

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted Therapy

University of Calgary · 9/27/2024

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder

Icahn School of Medicine at Mount Sinai · 9/19/2024

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression

Massachusetts General Hospital · 9/19/2024

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Oropharyngeoesophageal Topical Anesthesia Versus Propofol - Ketamine Sedation for Upper Gastrointestinal Endoscopy

Zagazig University · 8/22/2024

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Investigation to Understand and Optimize Psilocybin

Vail Health Behavioral Health · 7/22/2024

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression

University Health Network, Toronto · 7/17/2024

psilocybinmechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

The Effect of Ketamine on Sleep Quality in Patients Undergoing Colonoscopy

Kocaeli City Hospital · 7/12/2024

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial

University Health Network, Toronto · 6/28/2024

ketamineclinical-evidence
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psychedelic-assisted Group Program for First Responders

Empower Research Inc · 6/24/2024

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine

Assistance Publique - Hôpitaux de Paris · 6/18/2024

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence

University of Colorado, Denver · 5/28/2024

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine for Sedation in Severe Traumatic Brain Injury

Henry M. Jackson Foundation for the Advancement of Military Medicine · 5/28/2024

ketaminemechanisms
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Dose Optimization of MDMA-Assisted Therapy for PTSD

Bronx VA Medical Center · 5/17/2024

mdmaveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Comparison Between Ketamine Intrathecal and iv Dexamethasone for Post Cesarean Analgesia

Assiut University · 5/10/2024

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Study of Psilocybin for Anorexia in Young Adults

University of California, San Francisco · 5/3/2024

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSD

Unity Health Toronto · 4/26/2024

psilocybinveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP)

University of Wisconsin, Madison · 4/22/2024

ketamineveterans
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults

University of California, Berkeley · 4/16/2024

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Propofol or Benzodiazepine Combined With Ketamine for Procedural Sedation in Emergency Setting

Alexandria University · 4/16/2024

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

The Impact of Psilocybin on Pain in Fibromyalgia Patients

Maastricht University · 4/16/2024

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Nebulized Ketamine to Nebulized Fentanyl for Treating Acute Painful Conditions in the ED

Maimonides Medical Center · 4/15/2024

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of Psilocybin

University Health Network, Toronto · 4/2/2024

psilocybin
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
clinical-trial
submitted

The Effect of Preprocedural Subanesthetic Ketamine on Pain and Anxiety

Ankara Ataturk Sanatorium Training and Research Hospital · 3/15/2024

ketamine
Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.
Open source
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