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Preprints
32 records available.

Public manuscripts that may not have completed peer review and may change or be withdrawn.

Educational boundary. Automatically detected metadata is not a medical conclusion, endorsement, or quality rating. Open the source, examine methods and population, and wait for appropriate review before applying a finding.

Ledger source: Database ledger. Last collected/checked: Nov 13, 2026, 5:16 AM UTC. This ledger timestamp is within the last 48 hours.

preprint
submitted

DMT and harmine responses in monocyte-derived microglia- like cells from patients with treatment-resistant depression

Europe PMC · 11/11/2026

dmt

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Exploring subacute effects of a DMT and harmine meditation retreat on the brain's control energy landscape

Europe PMC · 11/11/2026

dmtmechanisms

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

A Placebo Cannot Be Psychedelic: Why psychedelic trials need dose, not mimicry, as their control

Europe PMC · 11/10/2026

clinical-evidence

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preprint
submitted

Beyond dose. Perceived group support as a person-level predictor of emotional breakthrough and psychological insight during DMT–harmine administration

Europe PMC · 11/10/2026

dmt

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Rapid antidepressant effects of psilocybin without increased SV2A binding: baseline binding predicts response

Europe PMC · 11/8/2026

psilocybin

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preprint
submitted

A Topology of the Psilocybin Experience Reveals Cognitive-Emotional Drivers, Unitive State Divergence, and Psychometric Feature Cancellation

Europe PMC · 11/5/2026

psilocybin

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Context-dependent effects of ketamine on emotional evidence integration

Europe PMC · 11/4/2026

ketamineintegration

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Scn2a -deficient mice exhibit serotonergic dysfunction and altered behavioral responses to psilocybin

Europe PMC · 11/4/2026

psilocybin

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Dyskinesia induced by a dopamine 2 receptor-like agonist, but not a dopamine 1 receptor-like agonist, is blocked by sub-anesthetic ketamine

Europe PMC · 11/3/2026

ketaminemechanisms

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preprint
submitted

The anti-dyskinetic and the anti-parkinsonian effects of sub-anesthetic ketamine are also present in female preclinical models

Europe PMC · 11/3/2026

ketamine

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preprint
submitted

Mapping Endogenous Psychedelic Chemistry: Indolethylamine N -Methyltransferase (INMT) Localizes Proximal to the Golgi Apparatus of Human Neurons

Europe PMC · 11/2/2026

mechanisms

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preprint
submitted

Post-psychedelic and meditation-related challenges: a protocol for a mixed-methods longitudinal-observational study

medRxiv · 10/29/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Neuroprotective activity of sub-anesthetic ketamine in a preclinical model of Parkinson’s disease is not blocked by antagonizing brain-derived neurotrophic factor signaling

Europe PMC · 10/29/2026

ketaminemechanisms

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Multi-scale effects of single-dose psilocybin in the macaque brain

Europe PMC · 10/29/2026

psilocybinmechanisms

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preprint
submitted

Item-Level Symptom Trajectories Across the PHQ-9 During At-Home Ketamine-Assisted Therapy for Depression: A Real-World Retrospective Analysis of 36,847 Adults

Europe PMC · 10/27/2026

ketamine

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Independent evolution of harmala alkaloids in medicinal Syrian rue and ayahuasca plants

Europe PMC · 10/27/2026

ayahuasca

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

From Acute MDMA Experiences to Lasting Change: Self-Compassion’s Role in MDMA-Assisted Psychotherapy for Social Anxiety Disorder

Europe PMC · 10/25/2026

mdma

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Drug exposure during oxycodone–S-ketamine patient-controlled analgesia reflects pain-related dosing behaviour after lumbar fusion surgery

Europe PMC · 10/21/2026

ketamine

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Beyond Symptom Reduction: Interconnectedness and Self-Transcendent Emotions During MDMA Sessions Predict Flourishing, Not Symptom Change, in Social Anxiety Disorder Treatment

Europe PMC · 10/20/2026

mdma

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Neural correlates of ketamine-induced dilation of temporal expectation

Europe PMC · 10/19/2026

ketamine

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Comparative chromosome-scale genomics of the ayahuasca liana Banisteriopsis caapi reveals paleopolyploid ancestry and recent tandem-gene expansions as candidate signatures of ethnovariety differentiation

Europe PMC · 10/16/2026

ayahuasca

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Context Shapes Alpha-Band Electrophysiological Signatures under Psilocybin

Europe PMC · 10/16/2026

psilocybin

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Dose-dependent modulation of visual imagery by Ayahuasca and dampening of visual processing away from external input: a placebo-controlled pharmacoimaging study

Europe PMC · 10/5/2026

ayahuasca

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preprint
submitted

An Open-Label Multidose Psilocybin Intervention for Obsessive-Compulsive Disorder.

Europe PMC · 10/5/2026

psilocybin

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Through the PRISM: Reinterpreting Psychedelic Cognition as Motivational Reallocation

Europe PMC · 10/2/2026

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Extracellular flux analysis and proteomic profiling indicate ibogaine promotes synaptic plasticity and neural repair by a metabolic preconditioning mechanism

Europe PMC · 10/2/2026

ibogaineibogamechanisms

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preprint
submitted

Mechanisms of anti-depressant and anti- alcohol effects of ketamine in patients with alcohol use disorder

Europe PMC · 9/30/2026

ketaminemechanisms

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Psilocybin and Contrasting Musical Compositions: Effects on Music-Evoked Emotional Responses in Healthy Adults

Europe PMC · 9/23/2026

psilocybin

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Therapeutic Alliance and Perceived Closeness in MDMA-Assisted Therapy for Social Anxiety Disorder

Europe PMC · 9/11/2026

mdma

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

A Two-Threshold Model of Psilocybin Response Explains Variability in Psychedelic-Assisted Therapy for Treatment-Resistant Depression

Europe PMC · 9/9/2026

psilocybin

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

Who Is Reached by Supervised Psilocybin Services? Oregon Services Versus National Psilocybin Use

Europe PMC · 9/7/2026

psilocybin

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

preprint
submitted

In Vitro Ketamine Attenuates Immune Sensitization in Major Depressive Disorder in a Concentration-Dependent Manner

medRxiv · 9/2/2026

ketamine

Automated discovery metadata only. Human editorial and qualified review are required before interpreting findings or changing care.

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